PATCHGAN PARADOX/ brats-2020
Dataset BraTS 2020 · 369 volumes Ablation Models A–D Runs 5 × 35 epochs Compute 12.2 GPU-h Author Dhruv Gupta · Bennett University
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U-Net - earlier exploratory run

sybau1 (1).ipynb

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Brain Tumor Segmentation – U-Net on BraTS 2020

This notebook trains a 3D U-Net for brain tumor segmentation using the BraTS 2020 dataset.

In [8]:
import os
import cv2
import random
import glob
import PIL
import shutil
import numpy as np
import pandas as pd
import matplotlib
import matplotlib.pyplot as plt
from skimage import data
from skimage.util import montage
import skimage.transform as skTrans
from skimage.transform import rotate
from skimage.transform import resize
from PIL import Image, ImageOps
import nibabel as nib
import keras
import keras.backend as K
from keras.callbacks import CSVLogger
import tensorflow as tf
from tensorflow.keras.utils import plot_model
from sklearn.preprocessing import MinMaxScaler
from sklearn.model_selection import train_test_split
from sklearn.metrics import classification_report
from tensorflow.keras.models import *
from tensorflow.keras.layers import *
from tensorflow.keras.optimizers import *
from tensorflow.keras.callbacks import ModelCheckpoint, ReduceLROnPlateau, EarlyStopping, TensorBoard
from tensorflow.keras.layers.experimental import preprocessing
2026-03-14 18:07:20.982812: E external/local_xla/xla/stream_executor/cuda/cuda_dnn.cc:9261] Unable to register cuDNN factory: Attempting to register factory for plugin cuDNN when one has already been registered
2026-03-14 18:07:20.982918: E external/local_xla/xla/stream_executor/cuda/cuda_fft.cc:607] Unable to register cuFFT factory: Attempting to register factory for plugin cuFFT when one has already been registered
2026-03-14 18:07:21.124041: E external/local_xla/xla/stream_executor/cuda/cuda_blas.cc:1515] Unable to register cuBLAS factory: Attempting to register factory for plugin cuBLAS when one has already been registered
---------------------------------------------------------------------------
ModuleNotFoundError                       Traceback (most recent call last)
Cell In[8], line 30
     28 from tensorflow.keras.optimizers import *
     29 from tensorflow.keras.callbacks import ModelCheckpoint, ReduceLROnPlateau, EarlyStopping, TensorBoard
---> 30 from tensorflow.keras.layers.experimental import preprocessing

ModuleNotFoundError: No module named 'tensorflow.keras.layers.experimental'
In [11]:
import os

MY_FILE = "/kaggle/input/datasets/dhruvgupta1402/brats20-training-355-seg-nii"  

# 2. The original file path that the notebook wants to use
ORIGINAL_FILE = "/kaggle/input/brats20-dataset-training-validation/BraTS2020_TrainingData/MICCAI_BraTS2020_TrainingData/BraTS20_Training_355/W39_1998.09.19_Segm.nii"

if os.path.exists(MY_FILE):
    override_path = "/kaggle/working/BraTS20_Training_355_seg.nii"
    if not os.path.exists(override_path):
        os.symlink(MY_FILE, override_path)
        print("Success: Created symlink → all code will now use your renamed file")
        print("Symlink path:", override_path)
    else:
        print("Override already exists")
else:
    print("Warning: Your uploaded file not found at:", MY_FILE)
    print("Make sure you added your dataset via + Add Data and path is correct")
Success: Created symlink → all code will now use your renamed file
Symlink path: /kaggle/working/BraTS20_Training_355_seg.nii
In [12]:
TRAIN_DATASET_PATH = "/kaggle/input/brats20-dataset-training-validation/BraTS2020_TrainingData/MICCAI_BraTS2020_TrainingData/"
In [13]:
# load .nii file as a numpy array
test_image_flair = nib.load(TRAIN_DATASET_PATH + "BraTS20_Training_355/BraTS20_Training_355_flair.nii").get_fdata()
print("Shape: ", test_image_flair.shape)
print("Dtype: ", test_image_flair.dtype)
Shape:  (240, 240, 155)
Dtype:  float64
In [5]:
print("Min: ", test_image_flair.min())
print("Max: ", test_image_flair.max())
Min:  0.0
Max:  1854.603271484375

As we can see the maximum pixel value of the image is 1854.6 which gives us a good idea to rescale these values. Rescaling pixel values is essential because it standardizes the intensity values across multimodal MRI scans (T1, T1ce, T2, FLAIR) to a uniform scale. This uniformity is crucial for consistent model training and analysis, as it ensures that variations in pixel intensity due to different imaging modalities and equipment do not bias the segmentation model. It facilitates the model's ability to learn meaningful features from the data for accurate tumor segmentation, regardless of the inherent differences in the raw MRI scans.

In [6]:
scaler = MinMaxScaler()
In [7]:
# Scale the test_image_flair array and then reshape it back to its original dimensions.
# This ensures the data is normalized/standardized for model input without altering its spatial structure.
test_image_flair = scaler.fit_transform(test_image_flair.reshape(-1, test_image_flair.shape[-1])).reshape(test_image_flair.shape)
In [8]:
print("Min: ", test_image_flair.min())
print("Max: ", test_image_flair.max())
Min:  0.0
Max:  1.0
In [13]:
# rescaling t1
test_image_t1 = nib.load(TRAIN_DATASET_PATH + 'BraTS20_Training_355/BraTS20_Training_355_t1.nii').get_fdata()
test_image_t1 = scaler.fit_transform(test_image_t1.reshape(-1, test_image_t1.shape[-1])).reshape(test_image_t1.shape)

# rescaling t1ce
test_image_t1ce = nib.load(TRAIN_DATASET_PATH + 'BraTS20_Training_355/BraTS20_Training_355_t1ce.nii').get_fdata()
test_image_t1ce = scaler.fit_transform(test_image_t1ce.reshape(-1, test_image_t1ce.shape[-1])).reshape(test_image_t1ce.shape)

# rescaling t2
test_image_t2 = nib.load(TRAIN_DATASET_PATH + 'BraTS20_Training_355/BraTS20_Training_355_t2.nii').get_fdata()
test_image_t2 = scaler.fit_transform(test_image_t2.reshape(-1, test_image_t2.shape[-1])).reshape(test_image_t2.shape)

# we will not rescale the mask
test_image_seg = nib.load('/kaggle/input/datasets/dhruvgupta1402/brats20-training-355-seg-nii/BraTS20_Training_355_seg.nii').get_fdata()
In [14]:
slice = 95

print("Slice Number: " + str(slice))

plt.figure(figsize=(12, 8))

# T1
plt.subplot(2, 3, 1)
plt.imshow(test_image_t1[:,:,slice], cmap='gray')
plt.title('T1')

# T1ce
plt.subplot(2, 3, 2)
plt.imshow(test_image_t1ce[:,:,slice], cmap='gray')
plt.title('T1ce')

# T2
plt.subplot(2, 3, 3)
plt.imshow(test_image_t2[:,:,slice], cmap='gray')
plt.title('T2')

# Flair
plt.subplot(2, 3, 4)
plt.imshow(test_image_flair[:,:,slice], cmap='gray')
plt.title('FLAIR')

# Mask
plt.subplot(2, 3, 5)
plt.imshow(test_image_seg[:,:,slice])
plt.title('Mask')
plt.show()
Slice Number: 95
No description has been provided for this image

The four imaging modalities provide distinct perspectives on the same brain image, each highlighting different features.

Detailed Description of Each Modality:

  1. Native (T1): This modality reveals the structure and composition of various tissue types in the brain. It's instrumental in identifying tumors, cysts, and other abnormalities.
  2. Post-contrast T1-weighted (T1ce, also known as T1Gd): Similar to T1 images, but enhanced with a contrast agent (Gadolinium), which improves the visibility of abnormalities.
  3. T2-weighted (T2): This modality highlights the fluid content within brain tissues.
  4. T2-FLAIR (T2 - Fluid Attenuated Inversion Recovery): This technique suppresses the fluid signals, making it easier to identify lesions that may not be visible on T1 or T2 images. It is particularly useful for detecting lesions in the brain's white matter, which are challenging to spot with other scans.

For medical experts, these four modalities collectively provide a comprehensive view, aiding in precise tumor analysis and confirmation. However, in our artificial intelligence approach, we aim to streamline the process by reducing computational and memory demands. Utilizing only two modalities can achieve this, making the segmentation task faster and more efficient.

To optimize our model, we will exclude the T1 modality since its enhanced counterpart, T1ce, provides better clarity. Similarly, we will omit the T2 modality because the fluids it highlights could negatively impact our predictions. Instead, the T2-FLAIR modality, which effectively highlights affected regions by suppressing fluid signals, will be more beneficial for our training.

Images Format

You may have noticed that these images are in the .nii format. These scans are NIfTI files (Neuroimaging Informatics Technology Initiative). A NIfTI image provides a digital representation of a 3D object, such as a brain in our case. The NIfTI format is widely used in neuroimaging because it efficiently handles complex, multi-dimensional data and includes metadata for spatial orientation and scaling.

To gain a better understanding of the data structure, let's examine the shape of a modality scan and a segmentation mask. Note that in this dataset, all modalities and their corresponding segmentation masks share the same dimensions:

In [15]:
# Modality shape
print("Modality: ", test_image_t1.shape)

# Segmentation shape
print("Segmentation: ", test_image_seg.shape)
Modality:  (240, 240, 155)
Segmentation:  (240, 240, 155)

As we can see, the modalities and segmentations have 3 dimensions. Each dimension consists of a series of two-dimensional images, known as slices, which all contain the same number of pixels and are stacked together to create this 3D representation. For instance, in our previous example, we displayed the 95th slice of a certain dimension.

These 3 dimensions correspond to the three spatial dimensions of the image: width, height, and depth. In medical imaging, these dimensions are referred to as the axial (transverse), coronal, and sagittal planes, corresponding to the three main orientations of the human body and, therefore, the human brain.

Here is a quick presentation of these 3 planes:

  1. Axial (Transverse) Plane: This plane divides the body into upper and lower parts and is perpendicular to the long axis of the body. In brain imaging, an axial slice is a horizontal cut through the brain.
  2. Coronal (Frontal) Plane: This plane divides the body into front (anterior) and back (posterior) parts. A coronal slice in brain imaging is a vertical cut from one side of the head to the other, dividing the brain into front and back sections.
  3. Sagittal (Lateral) Plane: This plane divides the body into left and right parts. A sagittal slice in brain imaging is a vertical cut from front to back, dividing the brain into left and right sections.

Understanding these planes is crucial for accurately interpreting medical images and effectively utilizing them in segmentation tasks. Each plane provides a different perspective, helping to localize and identify anatomical structures and abnormalities.

In [16]:
slice = 95

print("Slice number: " + str(slice))

plt.figure(figsize=(12, 8))

# Apply a 90° rotation with an automatic resizing, otherwise the display is less obvious to analyze
# T1 - Transverse View
plt.subplot(1, 3, 1)
plt.imshow(test_image_t1ce[:,:,slice], cmap='gray')
plt.title('T1 - Transverse View')

# T1 - Frontal View
plt.subplot(1, 3, 2)
plt.imshow(rotate(test_image_t1ce[:,slice,:], 90, resize=True), cmap='gray')
plt.title('T1 - Frontal View')

# T1 - Sagittal View
plt.subplot(1, 3, 3)
plt.imshow(rotate(test_image_t1ce[slice,:,:], 90, resize=True), cmap='gray')
plt.title('T1 - Sagittal View')
plt.show()
Slice number: 95
No description has been provided for this image

This visualization helps illustrate how each plane cuts through the brain and highlights different anatomical features, aiding in comprehensive analysis and segmentation.


Now that we understand the three dimensions, let's explore why we chose to display a specific slice, setting the slice number to 95. By examining all the slices, we can identify the slice that best represents the region of interest, such as the area where a tumor is located.

To visualize this, we will display all the slices along one dimension:

In [17]:
plt.figure(figsize=(10, 10))
plt.subplot(1, 1, 1)

# montage allows us to concatenate multiple images of the same size horizontally and vertically
plt.imshow(rotate(montage(test_image_t1ce[:,:,:]), 90, resize=True), cmap ='gray');
No description has been provided for this image

As you can see, two black parts are present on each side of our montage. These black parts correspond to the first and last slices of the plane. This indicates that a large portion of the slices does not contain much information, which is expected as the slices progressively represent the brain from one end to the other.

This observation is consistent across all modalities, planes, and even the expert-segmented images. The experts were unable to segment the slices that lack significant information, as these slices mostly capture areas outside the brain or the outermost regions that do not contain relevant anatomical details.

To further illustrate this, let's visualize a range of slices:

In [18]:
# Skip 50:-50 slices since there is not much to see
plt.figure(figsize=(10, 10))
plt.subplot(1, 1, 1)
plt.imshow(rotate(montage(test_image_t1ce[50:-50,:,:]), 90, resize=True), cmap ='gray');
No description has been provided for this image
In [19]:
# Skip 50:-50 slices since there is not much to see
plt.figure(figsize=(10, 10))
plt.subplot(1, 1, 1)
plt.imshow(rotate(montage(test_image_seg[50:-50,:,:]), 90, resize=True), cmap ='gray');
No description has been provided for this image

By focusing on a range of slices that contain meaningful content, we can better understand the anatomical structures and the regions where abnormalities, such as tumors, may be present. This approach helps in identifying the slices that are most relevant for analysis and segmentation.

This analysis applies to all other modalities and planes as well. The segmented images by experts also reflect this pattern, as they concentrate on the slices containing significant information. Slices that do not capture much of the brain's anatomy are often left unsegmented, as they provide little to no valuable data for diagnosis or analysis.

Now, let's focus on the segmentations provided by the experts. These segmentations provide critical information about the tumor:

  1. Location: Identifies the exact location of the tumor in the brain.
  2. Size and Shape: Measures the tumor's dimensions and form.
  3. Type: Helps differentiate between various tumor types.
  4. Heterogeneity: Reveals different components within the tumor (e.g., solid tissue, necrotic areas).
  5. Surrounding Tissue Involvement: Shows how the tumor interacts with adjacent brain structures.
  6. Cross-Modality Comparison: Provides a comprehensive view by comparing different imaging modalities.
In [20]:
# Plotting the segmantation
cmap = matplotlib.colors.ListedColormap(['#440054', '#3b528b', '#18b880', '#e6d74f'])
norm = matplotlib.colors.BoundaryNorm([-0.5, 0.5, 1.5, 2.5, 3.5], cmap.N)

# plotting the 95th slice
plt.imshow(test_image_seg[:,:,95], cmap=cmap, norm=norm)
plt.colorbar()
plt.show()
No description has been provided for this image
In [21]:
# Isolation of class 0
seg_0 = test_image_seg.copy()
seg_0[seg_0 != 0] = np.nan

# Isolation of class 1
seg_1 = test_image_seg.copy()
seg_1[seg_1 != 1] = np.nan

# Isolation of class 2
seg_2 = test_image_seg.copy()
seg_2[seg_2 != 2] = np.nan

# Isolation of class 4
seg_4 = test_image_seg.copy()
seg_4[seg_4 != 4] = np.nan

# Define legend
class_names = ['class 0', 'class 1', 'class 2', 'class 4']
legend = [plt.Rectangle((0, 0), 1, 1, color=cmap(i), label=class_names[i]) for i in range(len(class_names))]

fig, ax = plt.subplots(1, 5, figsize=(20, 20))

ax[0].imshow(test_image_seg[:,:, slice], cmap=cmap, norm=norm)
ax[0].set_title('Original Segmentation')
ax[0].legend(handles=legend, loc='lower left')

ax[1].imshow(seg_0[:,:, slice], cmap=cmap, norm=norm)
ax[1].set_title('Not Tumor (class 0)')

ax[2].imshow(seg_1[:,:, slice], cmap=cmap, norm=norm)
ax[2].set_title('Non-Enhancing Tumor (class 1)')

ax[3].imshow(seg_2[:,:, slice], cmap=cmap, norm=norm)
ax[3].set_title('Edema (class 2)')

ax[4].imshow(seg_4[:,:, slice], cmap=cmap, norm=norm)
ax[4].set_title('Enhancing Tumor (class 4)')

plt.show()
No description has been provided for this image

These insights are essential for accurate diagnosis, treatment planning, and monitoring. The segmentations help visualize the tumor clearly, making it easier to understand its characteristics and interactions with surrounding tissues.


To summarize our data exploration:

  • Modalities: Each sample/patient has 4 different modalities (T1, T1CE, T2, and FLAIR), accompanied by a segmentation indicating tumor areas.
  • Selected Modalities: We will focus on T1CE and FLAIR as they provide complementary information about the brain's anatomy and tissue contrast.
  • 3D Images: Each image is 3D and can be analyzed through 3 different planes composed of 2D slices.
  • Informative Slices: Many slices contain little or no information. We will use slices in the (50:-50) interval. You can customize this range, but note that changing it may affect training time.
  • Segmentation Classes: Segmentation images contain 1 to 4 classes. Class 4 will be reassigned to 3 since class 3 is missing.
  • Background Class: Class 0 (background) is over-represented. Cropping might remove important information, so we will keep the images as they are.

Now that we understand our data better, it's time to prepare for model training.

5. Split the Dataset

To train and evaluate our model effectively, we need to split our dataset into three parts: the training set (70-80%) for training the model, the validation set (10-15%) for tuning hyperparameters and preventing overfitting, and the test set (10-15%) for evaluating the final model's performance. We can use random splitting to divide the data or stratified splitting to maintain the same class distribution across sets, which is particularly useful for imbalanced datasets. Properly splitting the dataset ensures that our model is robust and performs well on unseen data.

In [14]:
# lists of directories with studies
train_and_val_directories = [f.path for f in os.scandir(TRAIN_DATASET_PATH) if f.is_dir()]

def pathListIntoIds(dirList):
    x = []
    for i in range(0,len(dirList)):
        x.append(dirList[i][dirList[i].rfind('/')+1:])
    return x

train_and_test_ids = pathListIntoIds(train_and_val_directories);

train_test_ids, val_ids = train_test_split(train_and_test_ids,test_size=0.2)
train_ids, test_ids = train_test_split(train_test_ids,test_size=0.15)
In [15]:
# Print data distribution (Train: 68%, Test: 12%, Val: 20%)
print(f"Train length: {len(train_ids)}")
print(f"Validation length: {len(val_ids)}")
print(f"Test length: {len(test_ids)}")
Train length: 250
Validation length: 74
Test length: 45
In [25]:
plt.bar(["Train","Valid","Test"],
        [len(train_ids), len(val_ids), len(test_ids)],
        align='center',
        color=[ 'green','red', 'blue'],
        label=["Train", "Valid", "Test"]
       )

plt.legend()

plt.ylabel('Number of Images')
plt.title('Data Distribution')

plt.show()
No description has been provided for this image

6. DataGenerator

To train a neural network for image segmentation, we need both raw image data (X) and ground truth segmentations (y). This allows the network to learn tumor patterns and make accurate predictions from patient scans. However, directly loading all 3D images can overload system memory and cause shape mismatch errors. Therefore, we use a Data Generator for image preprocessing, which includes several steps:

  1. Retrieve paths: Obtain the paths for the T1CE and FLAIR modalities (for complementary anatomical and tissue contrast information) and the ground truth segmentation.
  2. Load data: Load the selected slices (60-135) from these modalities and the corresponding segmentation.
  3. Create arrays: Form X arrays with the slices from T1CE and FLAIR, and y arrays with the segmentation slices.
  4. Class reassignment: Assign a value of 3 to all instances of 4 in the mask array to correct the missing class issue.

Additional preprocessing steps include:

  • Axial plane: Use the axial plane for its square shape (240x240). This enables visualizing predictions across all planes without impact.
  • One-Hot Encoding: Apply One-Hot Encoding to the y array to convert classes (0 to 3) into a numerical format suitable for neural networks, avoiding any implied hierarchy between classes. Here is what it consists of, for one slice: one_hot_encoding.png
  • Resize images: Resize each slice from (240x240) to (128x128). This shape is chosen because it is a power of two, fitting well with pooling layers (MaxPooling2D) in CNNs, and balances computational efficiency and information preservation.

While resizing to (256x256) could retain more detail, it significantly increases training time and memory usage. We can choose to train with (256x256) images, but we’ll need to adjust your U-Net architecture accordingly.

Now that we have a clear understanding of our data and preprocessing steps, we can proceed to prepare our model for training.

In [16]:
# Define seg-areas
SEGMENT_CLASSES = {
    0 : 'NOT tumor',
    1 : 'NECROTIC/CORE', # or NON-ENHANCING tumor CORE
    2 : 'EDEMA',
    3 : 'ENHANCING' # original 4 -> converted into 3
}

# Select Slices and Image Size
VOLUME_SLICES = 100
VOLUME_START_AT = 22 # first slice of volume that we will include
IMG_SIZE=128
In [87]:
import os

# Function to filter out any patients missing their segmentation mask
def clean_id_list(id_list):
    cleaned_list = []
    for patient_id in id_list:
        # Construct the exact path the generator will look for
        case_path = os.path.join(TRAIN_DATASET_PATH, patient_id)
        seg_path = os.path.join(case_path, f'{patient_id}_seg.nii')
        
        # Only keep the ID if the file actually exists on the hard drive
        if os.path.exists(seg_path):
            cleaned_list.append(patient_id)
        else:
            print(f"🗑️ Removed corrupted/missing patient: {patient_id}")
            
    return cleaned_list

# Clean all three lists
print("Scanning lists for corrupted files...")
train_ids = clean_id_list(train_ids)
val_ids = clean_id_list(val_ids)
test_ids = clean_id_list(test_ids)

# Re-initialize the generators with the cleaned lists
training_generator = DataGenerator(train_ids)
valid_generator = DataGenerator(val_ids)
test_generator = DataGenerator(test_ids)
Scanning lists for corrupted files...
🗑️ Removed corrupted/missing patient: BraTS20_Training_355
In [90]:
class DataGenerator(keras.utils.Sequence):
    'Generates data for Keras'
    def __init__(self, list_IDs, dim=(IMG_SIZE,IMG_SIZE), batch_size=1, n_channels=2, shuffle=True):
        'Initialization'
        self.dim = dim
        self.batch_size = batch_size
        self.list_IDs = list_IDs
        self.n_channels = n_channels
        self.shuffle = shuffle
        self.on_epoch_end()

    def __len__(self):
        'Denotes the number of batches per epoch'
        return int(np.floor(len(self.list_IDs) / self.batch_size))

    def __getitem__(self, index):
        'Generate one batch of data'
        indexes = self.indexes[index*self.batch_size:(index+1)*self.batch_size]
        Batch_ids = [self.list_IDs[k] for k in indexes]
        X, y = self.__data_generation(Batch_ids)
        return X, y

    def on_epoch_end(self):
        'Updates indexes after each epoch'
        self.indexes = np.arange(len(self.list_IDs))
        if self.shuffle == True:
            np.random.shuffle(self.indexes)

    def __data_generation(self, Batch_ids):
        'Generates data containing batch_size samples' 
        
        # FIX 1: Explicitly initialize arrays as float32
        X = np.zeros((self.batch_size*VOLUME_SLICES, *self.dim, self.n_channels), dtype=np.float32)
        y = np.zeros((self.batch_size*VOLUME_SLICES, 240, 240), dtype=np.float32)

        # Generate data
        for c, i in enumerate(Batch_ids):
            case_path = os.path.join(TRAIN_DATASET_PATH, i)

            data_path = os.path.join(case_path, f'{i}_flair.nii')
            flair = nib.load(data_path).get_fdata()

            data_path = os.path.join(case_path, f'{i}_t1ce.nii')
            t1ce = nib.load(data_path).get_fdata()

            data_path = os.path.join(case_path, f'{i}_seg.nii')
            seg = nib.load(data_path).get_fdata()

            for j in range(VOLUME_SLICES):
                 X[j +VOLUME_SLICES*c,:,:,0] = cv2.resize(flair[:,:,j+VOLUME_START_AT], (IMG_SIZE, IMG_SIZE))
                 X[j +VOLUME_SLICES*c,:,:,1] = cv2.resize(t1ce[:,:,j+VOLUME_START_AT], (IMG_SIZE, IMG_SIZE))
                 y[j +VOLUME_SLICES*c] = seg[:,:,j+VOLUME_START_AT]

        # Generate masks
        y[y==4] = 3
        mask = tf.one_hot(y, 4)
        Y = tf.image.resize(mask, (IMG_SIZE, IMG_SIZE))
        
        # FIX 2: Safely normalize X to prevent Division by Zero (NaNs)
        max_val = np.max(X)
        if max_val > 0:
            X = X / max_val
            
        # FIX 3: Convert TF Tensor 'Y' back to a standard numpy float32 array
        return np.array(X, dtype=np.float32), np.array(Y, dtype=np.float32)

# Reinitialize generators
training_generator = DataGenerator(train_ids)
valid_generator = DataGenerator(val_ids)
test_generator = DataGenerator(test_ids)

Preprocessing Steps Summary

  • Data Generator: Utilized to process and send data to the neural network without overloading memory.
  • Epoch Handling: For each epoch, the model processes 250 samples from the training dataset.
  • Sample Analysis: Each sample consists of 150 slices (100 slices each from two modalities) resized to (128, 128).
  • Data Shapes:
    • X Array: Shape (128, 128, 100, 2) for input images.
    • Ground Truth (y): One-Hot encoded segmentation with shape (100, 128, 128, 4).

This preprocessing setup ensures efficient data handling and preparation for training the neural network.

In [91]:
# Define a function to display one slice and its segmentation
def display_slice_and_segmentation(flair, t1ce, segmentation):
    fig, axes = plt.subplots(1, 3, figsize=(10, 5))

    axes[0].imshow(flair, cmap='gray')
    axes[0].set_title('Flair')
    axes[0].axis('off')

    axes[1].imshow(t1ce, cmap='gray')
    axes[1].set_title('T1CE')
    axes[1].axis('off')

    axes[2].imshow(segmentation) # Displaying segmentation
    axes[2].set_title('Segmentation')
    axes[2].axis('off')

    plt.tight_layout()
    plt.show()


# Retrieve the batch from the training generator
X_batch, Y_batch = training_generator[8]

# Extract Flair, T1CE, and segmentation from the batch
flair_batch = X_batch[:, :, :, 0]
t1ce_batch = X_batch[:, :, :, 1]
segmentation_batch = np.argmax(Y_batch, axis=-1)  # Convert one-hot encoded to categorical

# Extract the 50th slice from Flair, T1CE, and segmentation
slice_index = 60  # Indexing starts from 0
slice_flair = flair_batch[slice_index]
slice_t1ce = t1ce_batch[slice_index]
slice_segmentation = segmentation_batch[slice_index]

# Display the 50th slice and its segmentation
display_slice_and_segmentation(slice_flair, slice_t1ce, slice_segmentation)
No description has been provided for this image

7. Loss Function and Evaluation Metrics

Loss Function

When training a CNN, selecting an appropriate loss function is crucial for accurately reflecting the network's performance. This function compares the predicted pixels to the ground truth for each patient, guiding the model to update its weights to minimize the loss and improve prediction accuracy.

For multi-class classification problems, a commonly used loss function is categorical cross-entropy. This function measures the difference between the predicted probability distribution of each pixel and the one-hot encoded ground truth values. Additionally, segmentation models sometimes use the Dice loss function, which focuses on the overlap between the predicted and actual segments, further refining the accuracy of the segmentation.

Using these loss functions helps ensure that the model learns effectively and produces accurate segmentations of brain tumors.

In [95]:
import tensorflow as tf

# dice loss as defined above for 4 classes
def dice_coef(y_true, y_pred, smooth=1.0):
    class_num = 4
    total_loss = 0.0 # Initialize total_loss outside the loop for cleaner syntax
    
    for i in range(class_num):
        # Replace K.flatten with tf.reshape to flatten the arrays
        y_true_f = tf.reshape(y_true[:,:,:,i], [-1])
        y_pred_f = tf.reshape(y_pred[:,:,:,i], [-1])
        
        # Replace K.sum with tf.reduce_sum
        intersection = tf.reduce_sum(y_true_f * y_pred_f)
        loss = ((2. * intersection + smooth) / (tf.reduce_sum(y_true_f) + tf.reduce_sum(y_pred_f) + smooth))
        
        total_loss = total_loss + loss
        
    total_loss = total_loss / class_num
    return total_loss

Per Class Dice Coefficient Functions

These functions calculate the Dice coefficient for specific tumor classes in segmentation tasks, helping to measure the model's performance in predicting different tumor regions:

  • dice_coef_necrotic: Calculates the Dice coefficient for the necrotic (dead tissue) tumor region. It computes the intersection over the sum of squares of the true and predicted values for the necrotic class.

  • dice_coef_edema: Calculates the Dice coefficient for the edema (swelling) tumor region. It computes the intersection over the sum of squares of the true and predicted values for the edema class.

  • dice_coef_enhancing: Calculates the Dice coefficient for the enhancing tumor region. It computes the intersection over the sum of squares of the true and predicted values for the enhancing class.

In [98]:
import tensorflow as tf

# Define per class evaluation of dice coef
def dice_coef_necrotic(y_true, y_pred, epsilon=1e-6):
    # Replace K.sum, K.abs, and K.square with their tf equivalents
    intersection = tf.reduce_sum(tf.abs(y_true[:,:,:,1] * y_pred[:,:,:,1]))
    return (2. * intersection) / (tf.reduce_sum(tf.square(y_true[:,:,:,1])) + tf.reduce_sum(tf.square(y_pred[:,:,:,1])) + epsilon)

def dice_coef_edema(y_true, y_pred, epsilon=1e-6):
    intersection = tf.reduce_sum(tf.abs(y_true[:,:,:,2] * y_pred[:,:,:,2]))
    return (2. * intersection) / (tf.reduce_sum(tf.square(y_true[:,:,:,2])) + tf.reduce_sum(tf.square(y_pred[:,:,:,2])) + epsilon)

def dice_coef_enhancing(y_true, y_pred, epsilon=1e-6):
    intersection = tf.reduce_sum(tf.abs(y_true[:,:,:,3] * y_pred[:,:,:,3]))
    return (2. * intersection) / (tf.reduce_sum(tf.square(y_true[:,:,:,3])) + tf.reduce_sum(tf.square(y_pred[:,:,:,3])) + epsilon)

Each function includes a small constant (epsilon) to avoid division by zero.

Evaluation Metrics

To effectively monitor the model's performance, we use various evaluation metrics:

  • Accuracy: Measures the overall proportion of correctly classified pixels. However, it can be misleading with imbalanced datasets like BraTS2020, where the background class is overrepresented.
  • Intersection over Union (IoU): Measures the overlap between the predicted and ground truth segmentations.
  • Dice Coefficient: Evaluates the similarity between predicted and ground truth segmentations.
  • Sensitivity (Recall or True Positive Rate): Measures the proportion of positive ground truth pixels correctly predicted as positive.
  • Precision (Positive Predictive Value): Measures the proportion of predicted positive pixels that are actually positive.
  • Specificity (True Negative Rate): Measures the proportion of negative ground truth pixels correctly predicted as negative.

Using these metrics provides a comprehensive assessment of the model’s performance, addressing the limitations of using accuracy alone on imbalanced datasets.

In [99]:
import tensorflow as tf
import keras

# Computing Precision
def precision(y_true, y_pred):
    y_true_f = tf.cast(y_true, tf.float32)
    y_pred_f = tf.cast(y_pred, tf.float32)
    
    true_positives = tf.reduce_sum(tf.round(tf.clip_by_value(y_true_f * y_pred_f, 0.0, 1.0)))
    predicted_positives = tf.reduce_sum(tf.round(tf.clip_by_value(y_pred_f, 0.0, 1.0)))
    
    return true_positives / (predicted_positives + keras.backend.epsilon())


# Computing Sensitivity (Recall)
def sensitivity(y_true, y_pred):
    y_true_f = tf.cast(y_true, tf.float32)
    y_pred_f = tf.cast(y_pred, tf.float32)
    
    true_positives = tf.reduce_sum(tf.round(tf.clip_by_value(y_true_f * y_pred_f, 0.0, 1.0)))
    possible_positives = tf.reduce_sum(tf.round(tf.clip_by_value(y_true_f, 0.0, 1.0)))
    
    return true_positives / (possible_positives + keras.backend.epsilon())


# Computing Specificity
def specificity(y_true, y_pred):
    y_true_f = tf.cast(y_true, tf.float32)
    y_pred_f = tf.cast(y_pred, tf.float32)
    
    true_negatives = tf.reduce_sum(tf.round(tf.clip_by_value((1.0 - y_true_f) * (1.0 - y_pred_f), 0.0, 1.0)))
    possible_negatives = tf.reduce_sum(tf.round(tf.clip_by_value(1.0 - y_true_f, 0.0, 1.0)))
    
    return true_negatives / (possible_negatives + keras.backend.epsilon())

8. Define the Segmentation Model

U-Net

We will use the U-Net architecture, a convolutional neural network (CNN) specifically designed for biomedical image segmentation. U-Net is particularly effective for segmenting regions of interest that are small and have complex shapes, such as tumors in MRI scans. This architecture was introduced in 2015 by Olaf Ronneberger, Philipp Fischer, and Thomas Brox in their paper U-Net: Convolutional Networks for Biomedical Image Segmentation.

Since the BraTS2020 dataset consists of 3D images, with each image comprising multiple 2D slices in three orthogonal planes, we have two options: using a 2D U-Net or a 3D U-Net.

  • 3D U-Net: More suitable for leveraging the 3D spatial context of the images, reducing the risk of false positives and false negatives from partial information in individual slices. However, it requires more computational resources and memory.
  • 2D U-Net: Faster and requires less memory, advantageous when working with large datasets or limited computational resources.

In practice, it’s useful to try both architectures and compare their performance. We will opt for a 2D U-Net implementation due to its efficiency and lower resource requirements.

In [100]:
def build_unet(inputs, ker_init, dropout):
    conv1 = Conv2D(32, 3, activation = 'relu', padding = 'same', kernel_initializer = ker_init)(inputs)
    conv1 = Conv2D(32, 3, activation = 'relu', padding = 'same', kernel_initializer = ker_init)(conv1)

    pool = MaxPooling2D(pool_size=(2, 2))(conv1)
    conv = Conv2D(64, 3, activation = 'relu', padding = 'same', kernel_initializer = ker_init)(pool)
    conv = Conv2D(64, 3, activation = 'relu', padding = 'same', kernel_initializer = ker_init)(conv)

    pool1 = MaxPooling2D(pool_size=(2, 2))(conv)
    conv2 = Conv2D(128, 3, activation = 'relu', padding = 'same', kernel_initializer = ker_init)(pool1)
    conv2 = Conv2D(128, 3, activation = 'relu', padding = 'same', kernel_initializer = ker_init)(conv2)

    pool2 = MaxPooling2D(pool_size=(2, 2))(conv2)
    conv3 = Conv2D(256, 3, activation = 'relu', padding = 'same', kernel_initializer = ker_init)(pool2)
    conv3 = Conv2D(256, 3, activation = 'relu', padding = 'same', kernel_initializer = ker_init)(conv3)


    pool4 = MaxPooling2D(pool_size=(2, 2))(conv3)
    conv5 = Conv2D(512, 3, activation = 'relu', padding = 'same', kernel_initializer = ker_init)(pool4)
    conv5 = Conv2D(512, 3, activation = 'relu', padding = 'same', kernel_initializer = ker_init)(conv5)
    drop5 = Dropout(dropout)(conv5)

    up7 = Conv2D(256, 2, activation = 'relu', padding = 'same', kernel_initializer = ker_init)(UpSampling2D(size = (2,2))(drop5))
    merge7 = concatenate([conv3,up7], axis = 3)
    conv7 = Conv2D(256, 3, activation = 'relu', padding = 'same', kernel_initializer = ker_init)(merge7)
    conv7 = Conv2D(256, 3, activation = 'relu', padding = 'same', kernel_initializer = ker_init)(conv7)

    up8 = Conv2D(128, 2, activation = 'relu', padding = 'same', kernel_initializer = ker_init)(UpSampling2D(size = (2,2))(conv7))
    merge8 = concatenate([conv2,up8], axis = 3)
    conv8 = Conv2D(128, 3, activation = 'relu', padding = 'same', kernel_initializer = ker_init)(merge8)
    conv8 = Conv2D(128, 3, activation = 'relu', padding = 'same', kernel_initializer = ker_init)(conv8)

    up9 = Conv2D(64, 2, activation = 'relu', padding = 'same', kernel_initializer = ker_init)(UpSampling2D(size = (2,2))(conv8))
    merge9 = concatenate([conv,up9], axis = 3)
    conv9 = Conv2D(64, 3, activation = 'relu', padding = 'same', kernel_initializer = ker_init)(merge9)
    conv9 = Conv2D(64, 3, activation = 'relu', padding = 'same', kernel_initializer = ker_init)(conv9)

    up = Conv2D(32, 2, activation = 'relu', padding = 'same', kernel_initializer = ker_init)(UpSampling2D(size = (2,2))(conv9))
    merge = concatenate([conv1,up], axis = 3)
    conv = Conv2D(32, 3, activation = 'relu', padding = 'same', kernel_initializer = ker_init)(merge)
    conv = Conv2D(32, 3, activation = 'relu', padding = 'same', kernel_initializer = ker_init)(conv)

    conv10 = Conv2D(4, (1,1), activation = 'softmax')(conv)

    return Model(inputs = inputs, outputs = conv10)

Here is the visual representation of our model:

U-Net%20%281%29.png

Build and Plot the Model

In [101]:
input_layer = Input((IMG_SIZE, IMG_SIZE, 2))

model = build_unet(input_layer, 'he_normal', 0.2)

model.compile(loss="categorical_crossentropy",
              optimizer=keras.optimizers.Adam(learning_rate=0.001),
              metrics = ['accuracy',tf.keras.metrics.MeanIoU(num_classes=4), dice_coef, precision, sensitivity, specificity, dice_coef_necrotic, dice_coef_edema ,dice_coef_enhancing])
In [102]:
plot_model(model,
           show_shapes = True,
           show_dtype=False,
           show_layer_names = True,
           rankdir = 'TB',
           expand_nested = False,
           dpi = 70)
Out[102]:
No description has been provided for this image

Set up callbacks

In [103]:
callbacks = [
    keras.callbacks.ReduceLROnPlateau(
        monitor='val_loss',
        factor=0.2,
        patience=2,
        min_lr=0.000001,
        verbose=1
    ),
    
    keras.callbacks.ModelCheckpoint(
        filepath='model_.{epoch:02d}-{val_loss:.6f}.weights.h5',   # ← fixed extension
        verbose=1,
        save_best_only=True,
        save_weights_only=True
    ),
    
    keras.callbacks.CSVLogger(
        'training.log',
        separator=',',
        append=False
    )
]

9. Train and Save the Model

We are now ready to train our deep neural network using the .fit() method in Keras. We will pass our three callbacks to this method to be executed during the training process, which will last for 35 epochs.

In [35]:
print(f"Number of batches in training generator: {len(training_generator)}")
print(f"Number of batches in validation generator: {len(valid_generator)}")
Number of batches in training generator: 250
Number of batches in validation generator: 74
In [36]:
# Try to fetch the very first batch
X_batch, y_batch = training_generator[0]

print(f"X batch shape: {X_batch.shape}")
print(f"y batch shape: {y_batch.shape}")
X batch shape: (100, 128, 128, 2)
y batch shape: (100, 128, 128, 4)
In [104]:
import time
import keras

class CleanTimeStatsCallback(keras.callbacks.Callback):
    def on_train_begin(self, logs=None):
        self.train_start_time = time.time()
        print("🚀 Training started! (Displaying clean stats...)")

    def on_epoch_begin(self, epoch, logs=None):
        self.epoch_start_time = time.time()
        print(f"\n--- Epoch {epoch + 1}/{self.params['epochs']} ---")

    def on_train_batch_end(self, batch, logs=None):
        # Print batch 1 to confirm graph compilation, then just update every 50 batches
        if batch == 0:
            print(f"  ↳ Batch 1 compiled & completed!")
        elif (batch + 1) % 50 == 0:
            print(f"  ↳ Processing batch {batch + 1}...")

    def on_epoch_end(self, epoch, logs=None):
        epoch_duration = time.time() - self.epoch_start_time
        
        # Extract only the most vital metrics safely
        loss = logs.get('loss', 0.0)
        val_loss = logs.get('val_loss', 0.0)
        dice = logs.get('dice_coef', 0.0) 
        val_dice = logs.get('val_dice_coef', 0.0)
        
        print(f" ✅ Epoch {epoch + 1} Finished in {epoch_duration/60:.2f} mins")
        print(f" 📊 Loss: {loss:.4f} | Val Loss: {val_loss:.4f} | Dice: {dice:.4f} | Val Dice: {val_dice:.4f}")

    def on_train_end(self, logs=None):
        total_duration = time.time() - self.train_start_time
        print(f"\n🎉 Training Complete! Total Time: {total_duration/60:.2f} minutes")

# Add the clean callback to your list
my_callbacks = callbacks + [CleanTimeStatsCallback()] if isinstance(callbacks, list) else [callbacks, CleanTimeStatsCallback()]

# Run fit with verbose=0 to hide the messy default output
history = model.fit(
    training_generator,
    epochs=35,
    callbacks=my_callbacks,
    validation_data=valid_generator,
    verbose=0  # <--- This hides the massive block of Keras stats!
)
🚀 Training started! (Displaying clean stats...)

--- Epoch 1/35 ---
/opt/conda/lib/python3.10/site-packages/keras/src/trainers/data_adapters/py_dataset_adapter.py:121: UserWarning: Your `PyDataset` class should call `super().__init__(**kwargs)` in its constructor. `**kwargs` can include `workers`, `use_multiprocessing`, `max_queue_size`. Do not pass these arguments to `fit()`, as they will be ignored.
  self._warn_if_super_not_called()
  ↳ Batch 1 compiled & completed!
  ↳ Processing batch 50...
  ↳ Processing batch 100...
  ↳ Processing batch 150...
  ↳ Processing batch 200...

Epoch 1: val_loss improved from inf to 0.09746, saving model to model_.01-0.097464.weights.h5
 ✅ Epoch 1 Finished in 3.70 mins
 📊 Loss: 0.1136 | Val Loss: 0.0975 | Dice: 0.2657 | Val Dice: 0.2727

--- Epoch 2/35 ---
  ↳ Batch 1 compiled & completed!
  ↳ Processing batch 50...
  ↳ Processing batch 100...
  ↳ Processing batch 150...
  ↳ Processing batch 200...

Epoch 2: val_loss improved from 0.09746 to 0.07525, saving model to model_.02-0.075255.weights.h5
 ✅ Epoch 2 Finished in 2.49 mins
 📊 Loss: 0.0752 | Val Loss: 0.0753 | Dice: 0.2743 | Val Dice: 0.2790

--- Epoch 3/35 ---
  ↳ Batch 1 compiled & completed!
  ↳ Processing batch 50...
  ↳ Processing batch 100...
  ↳ Processing batch 150...
  ↳ Processing batch 200...

Epoch 3: val_loss improved from 0.07525 to 0.07500, saving model to model_.03-0.075004.weights.h5
 ✅ Epoch 3 Finished in 2.50 mins
 📊 Loss: 0.0693 | Val Loss: 0.0750 | Dice: 0.2807 | Val Dice: 0.2854

--- Epoch 4/35 ---
  ↳ Batch 1 compiled & completed!
  ↳ Processing batch 50...
  ↳ Processing batch 100...
  ↳ Processing batch 150...
  ↳ Processing batch 200...

Epoch 4: val_loss improved from 0.07500 to 0.06641, saving model to model_.04-0.066413.weights.h5
 ✅ Epoch 4 Finished in 2.52 mins
 📊 Loss: 0.0649 | Val Loss: 0.0664 | Dice: 0.2985 | Val Dice: 0.2845

--- Epoch 5/35 ---
  ↳ Batch 1 compiled & completed!
  ↳ Processing batch 50...
  ↳ Processing batch 100...
  ↳ Processing batch 150...
  ↳ Processing batch 200...

Epoch 5: val_loss improved from 0.06641 to 0.05761, saving model to model_.05-0.057606.weights.h5
 ✅ Epoch 5 Finished in 2.51 mins
 📊 Loss: 0.0637 | Val Loss: 0.0576 | Dice: 0.3124 | Val Dice: 0.3320

--- Epoch 6/35 ---
  ↳ Batch 1 compiled & completed!
  ↳ Processing batch 50...
  ↳ Processing batch 100...
  ↳ Processing batch 150...
  ↳ Processing batch 200...

Epoch 6: val_loss did not improve from 0.05761
 ✅ Epoch 6 Finished in 2.51 mins
 📊 Loss: 0.0545 | Val Loss: 0.0583 | Dice: 0.3453 | Val Dice: 0.3850

--- Epoch 7/35 ---
  ↳ Batch 1 compiled & completed!
  ↳ Processing batch 50...
  ↳ Processing batch 100...
  ↳ Processing batch 150...
  ↳ Processing batch 200...

Epoch 7: ReduceLROnPlateau reducing learning rate to 0.00020000000949949026.

Epoch 7: val_loss did not improve from 0.05761
 ✅ Epoch 7 Finished in 2.49 mins
 📊 Loss: 0.0554 | Val Loss: 0.0591 | Dice: 0.3598 | Val Dice: 0.3636

--- Epoch 8/35 ---
  ↳ Batch 1 compiled & completed!
  ↳ Processing batch 50...
  ↳ Processing batch 100...
  ↳ Processing batch 150...
  ↳ Processing batch 200...

Epoch 8: val_loss improved from 0.05761 to 0.04489, saving model to model_.08-0.044888.weights.h5
 ✅ Epoch 8 Finished in 2.50 mins
 📊 Loss: 0.0468 | Val Loss: 0.0449 | Dice: 0.3941 | Val Dice: 0.4120

--- Epoch 9/35 ---
  ↳ Batch 1 compiled & completed!
  ↳ Processing batch 50...
  ↳ Processing batch 100...
  ↳ Processing batch 150...
  ↳ Processing batch 200...

Epoch 9: val_loss did not improve from 0.04489
 ✅ Epoch 9 Finished in 2.46 mins
 📊 Loss: 0.0403 | Val Loss: 0.0489 | Dice: 0.4277 | Val Dice: 0.4000

--- Epoch 10/35 ---
  ↳ Batch 1 compiled & completed!
  ↳ Processing batch 50...
  ↳ Processing batch 100...
  ↳ Processing batch 150...
  ↳ Processing batch 200...

Epoch 10: val_loss improved from 0.04489 to 0.04147, saving model to model_.10-0.041468.weights.h5
 ✅ Epoch 10 Finished in 2.49 mins
 📊 Loss: 0.0380 | Val Loss: 0.0415 | Dice: 0.4394 | Val Dice: 0.4426

--- Epoch 11/35 ---
  ↳ Batch 1 compiled & completed!
  ↳ Processing batch 50...
  ↳ Processing batch 100...
  ↳ Processing batch 150...
  ↳ Processing batch 200...

Epoch 11: val_loss improved from 0.04147 to 0.03913, saving model to model_.11-0.039130.weights.h5
 ✅ Epoch 11 Finished in 2.49 mins
 📊 Loss: 0.0348 | Val Loss: 0.0391 | Dice: 0.4607 | Val Dice: 0.4554

--- Epoch 12/35 ---
  ↳ Batch 1 compiled & completed!
  ↳ Processing batch 50...
  ↳ Processing batch 100...
  ↳ Processing batch 150...
  ↳ Processing batch 200...

Epoch 12: val_loss improved from 0.03913 to 0.03819, saving model to model_.12-0.038189.weights.h5
 ✅ Epoch 12 Finished in 2.50 mins
 📊 Loss: 0.0333 | Val Loss: 0.0382 | Dice: 0.4721 | Val Dice: 0.4594

--- Epoch 13/35 ---
  ↳ Batch 1 compiled & completed!
  ↳ Processing batch 50...
  ↳ Processing batch 100...
  ↳ Processing batch 150...
  ↳ Processing batch 200...

Epoch 13: val_loss improved from 0.03819 to 0.03372, saving model to model_.13-0.033724.weights.h5
 ✅ Epoch 13 Finished in 2.50 mins
 📊 Loss: 0.0301 | Val Loss: 0.0337 | Dice: 0.4979 | Val Dice: 0.4918

--- Epoch 14/35 ---
  ↳ Batch 1 compiled & completed!
  ↳ Processing batch 50...
  ↳ Processing batch 100...
  ↳ Processing batch 150...
  ↳ Processing batch 200...

Epoch 14: val_loss improved from 0.03372 to 0.03249, saving model to model_.14-0.032495.weights.h5
 ✅ Epoch 14 Finished in 2.53 mins
 📊 Loss: 0.0282 | Val Loss: 0.0325 | Dice: 0.5135 | Val Dice: 0.5029

--- Epoch 15/35 ---
  ↳ Batch 1 compiled & completed!
  ↳ Processing batch 50...
  ↳ Processing batch 100...
  ↳ Processing batch 150...
  ↳ Processing batch 200...

Epoch 15: val_loss improved from 0.03249 to 0.03085, saving model to model_.15-0.030847.weights.h5
 ✅ Epoch 15 Finished in 2.54 mins
 📊 Loss: 0.0272 | Val Loss: 0.0308 | Dice: 0.5251 | Val Dice: 0.5121

--- Epoch 16/35 ---
  ↳ Batch 1 compiled & completed!
  ↳ Processing batch 50...
  ↳ Processing batch 100...
  ↳ Processing batch 150...
  ↳ Processing batch 200...

Epoch 16: val_loss improved from 0.03085 to 0.02968, saving model to model_.16-0.029676.weights.h5
 ✅ Epoch 16 Finished in 2.50 mins
 📊 Loss: 0.0251 | Val Loss: 0.0297 | Dice: 0.5467 | Val Dice: 0.5122

--- Epoch 17/35 ---
  ↳ Batch 1 compiled & completed!
  ↳ Processing batch 50...
  ↳ Processing batch 100...
  ↳ Processing batch 150...
  ↳ Processing batch 200...

Epoch 17: val_loss did not improve from 0.02968
 ✅ Epoch 17 Finished in 2.48 mins
 📊 Loss: 0.0239 | Val Loss: 0.0301 | Dice: 0.5542 | Val Dice: 0.5386

--- Epoch 18/35 ---
  ↳ Batch 1 compiled & completed!
  ↳ Processing batch 50...
  ↳ Processing batch 100...
  ↳ Processing batch 150...
  ↳ Processing batch 200...

Epoch 18: val_loss improved from 0.02968 to 0.02841, saving model to model_.18-0.028413.weights.h5
 ✅ Epoch 18 Finished in 2.48 mins
 📊 Loss: 0.0231 | Val Loss: 0.0284 | Dice: 0.5638 | Val Dice: 0.5449

--- Epoch 19/35 ---
  ↳ Batch 1 compiled & completed!
  ↳ Processing batch 50...
  ↳ Processing batch 100...
  ↳ Processing batch 150...
  ↳ Processing batch 200...

Epoch 19: val_loss did not improve from 0.02841
 ✅ Epoch 19 Finished in 2.49 mins
 📊 Loss: 0.0227 | Val Loss: 0.0302 | Dice: 0.5678 | Val Dice: 0.5469

--- Epoch 20/35 ---
  ↳ Batch 1 compiled & completed!
  ↳ Processing batch 50...
  ↳ Processing batch 100...
  ↳ Processing batch 150...
  ↳ Processing batch 200...

Epoch 20: ReduceLROnPlateau reducing learning rate to 4.0000001899898055e-05.

Epoch 20: val_loss did not improve from 0.02841
 ✅ Epoch 20 Finished in 2.48 mins
 📊 Loss: 0.0228 | Val Loss: 0.0310 | Dice: 0.5736 | Val Dice: 0.5240

--- Epoch 21/35 ---
  ↳ Batch 1 compiled & completed!
  ↳ Processing batch 50...
  ↳ Processing batch 100...
  ↳ Processing batch 150...
  ↳ Processing batch 200...

Epoch 21: val_loss improved from 0.02841 to 0.02654, saving model to model_.21-0.026537.weights.h5
 ✅ Epoch 21 Finished in 2.47 mins
 📊 Loss: 0.0200 | Val Loss: 0.0265 | Dice: 0.5899 | Val Dice: 0.5688

--- Epoch 22/35 ---
  ↳ Batch 1 compiled & completed!
  ↳ Processing batch 50...
  ↳ Processing batch 100...
  ↳ Processing batch 150...
  ↳ Processing batch 200...

Epoch 22: val_loss did not improve from 0.02654
 ✅ Epoch 22 Finished in 2.46 mins
 📊 Loss: 0.0189 | Val Loss: 0.0269 | Dice: 0.6053 | Val Dice: 0.5726

--- Epoch 23/35 ---
  ↳ Batch 1 compiled & completed!
  ↳ Processing batch 50...
  ↳ Processing batch 100...
  ↳ Processing batch 150...
  ↳ Processing batch 200...

Epoch 23: ReduceLROnPlateau reducing learning rate to 8.000000525498762e-06.

Epoch 23: val_loss did not improve from 0.02654
 ✅ Epoch 23 Finished in 2.48 mins
 📊 Loss: 0.0185 | Val Loss: 0.0266 | Dice: 0.6098 | Val Dice: 0.5730

--- Epoch 24/35 ---
  ↳ Batch 1 compiled & completed!
  ↳ Processing batch 50...
  ↳ Processing batch 100...
  ↳ Processing batch 150...
  ↳ Processing batch 200...

Epoch 24: val_loss did not improve from 0.02654
 ✅ Epoch 24 Finished in 2.48 mins
 📊 Loss: 0.0181 | Val Loss: 0.0269 | Dice: 0.6137 | Val Dice: 0.5790

--- Epoch 25/35 ---
  ↳ Batch 1 compiled & completed!
  ↳ Processing batch 50...
  ↳ Processing batch 100...
  ↳ Processing batch 150...
  ↳ Processing batch 200...

Epoch 25: ReduceLROnPlateau reducing learning rate to 1.6000001778593287e-06.

Epoch 25: val_loss did not improve from 0.02654
 ✅ Epoch 25 Finished in 2.46 mins
 📊 Loss: 0.0179 | Val Loss: 0.0271 | Dice: 0.6161 | Val Dice: 0.5812

--- Epoch 26/35 ---
  ↳ Batch 1 compiled & completed!
  ↳ Processing batch 50...
  ↳ Processing batch 100...
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Epoch 26: val_loss did not improve from 0.02654
 ✅ Epoch 26 Finished in 2.50 mins
 📊 Loss: 0.0178 | Val Loss: 0.0270 | Dice: 0.6177 | Val Dice: 0.5816

--- Epoch 27/35 ---
  ↳ Batch 1 compiled & completed!
  ↳ Processing batch 50...
  ↳ Processing batch 100...
  ↳ Processing batch 150...
  ↳ Processing batch 200...

Epoch 27: ReduceLROnPlateau reducing learning rate to 1e-06.

Epoch 27: val_loss did not improve from 0.02654
 ✅ Epoch 27 Finished in 2.48 mins
 📊 Loss: 0.0178 | Val Loss: 0.0270 | Dice: 0.6184 | Val Dice: 0.5820

--- Epoch 28/35 ---
  ↳ Batch 1 compiled & completed!
  ↳ Processing batch 50...
  ↳ Processing batch 100...
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Epoch 28: val_loss did not improve from 0.02654
 ✅ Epoch 28 Finished in 2.46 mins
 📊 Loss: 0.0177 | Val Loss: 0.0271 | Dice: 0.6186 | Val Dice: 0.5822

--- Epoch 29/35 ---
  ↳ Batch 1 compiled & completed!
  ↳ Processing batch 50...
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Epoch 29: val_loss did not improve from 0.02654
 ✅ Epoch 29 Finished in 2.47 mins
 📊 Loss: 0.0177 | Val Loss: 0.0271 | Dice: 0.6188 | Val Dice: 0.5824

--- Epoch 30/35 ---
  ↳ Batch 1 compiled & completed!
  ↳ Processing batch 50...
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Epoch 30: val_loss did not improve from 0.02654
 ✅ Epoch 30 Finished in 2.47 mins
 📊 Loss: 0.0177 | Val Loss: 0.0271 | Dice: 0.6190 | Val Dice: 0.5826

--- Epoch 31/35 ---
  ↳ Batch 1 compiled & completed!
  ↳ Processing batch 50...
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Epoch 31: val_loss did not improve from 0.02654
 ✅ Epoch 31 Finished in 2.49 mins
 📊 Loss: 0.0177 | Val Loss: 0.0271 | Dice: 0.6191 | Val Dice: 0.5828

--- Epoch 32/35 ---
  ↳ Batch 1 compiled & completed!
  ↳ Processing batch 50...
  ↳ Processing batch 100...
  ↳ Processing batch 150...
  ↳ Processing batch 200...

Epoch 32: val_loss did not improve from 0.02654
 ✅ Epoch 32 Finished in 2.49 mins
 📊 Loss: 0.0177 | Val Loss: 0.0272 | Dice: 0.6195 | Val Dice: 0.5830

--- Epoch 33/35 ---
  ↳ Batch 1 compiled & completed!
  ↳ Processing batch 50...
  ↳ Processing batch 100...
  ↳ Processing batch 150...
  ↳ Processing batch 200...

Epoch 33: val_loss did not improve from 0.02654
 ✅ Epoch 33 Finished in 2.50 mins
 📊 Loss: 0.0177 | Val Loss: 0.0271 | Dice: 0.6198 | Val Dice: 0.5831

--- Epoch 34/35 ---
  ↳ Batch 1 compiled & completed!
  ↳ Processing batch 50...
  ↳ Processing batch 100...
  ↳ Processing batch 150...
  ↳ Processing batch 200...

Epoch 34: val_loss did not improve from 0.02654
 ✅ Epoch 34 Finished in 2.48 mins
 📊 Loss: 0.0177 | Val Loss: 0.0271 | Dice: 0.6198 | Val Dice: 0.5831

--- Epoch 35/35 ---
  ↳ Batch 1 compiled & completed!
  ↳ Processing batch 50...
  ↳ Processing batch 100...
  ↳ Processing batch 150...
  ↳ Processing batch 200...

Epoch 35: val_loss did not improve from 0.02654
 ✅ Epoch 35 Finished in 2.49 mins
 📊 Loss: 0.0177 | Val Loss: 0.0271 | Dice: 0.6199 | Val Dice: 0.5832

🎉 Training Complete! Total Time: 88.32 minutes
In [105]:
model.save("my_model.keras")

10. Load the Trained Model

We will load our trained neural network model using Keras. The load_model method allows us to reload the saved model, including custom metrics and loss functions we defined during training. Here’s how we do it:

In [109]:
model = keras.models.load_model('/kaggle/working/my_model.keras',
                                   custom_objects={"accuracy" : tf.keras.metrics.MeanIoU(num_classes=4),
                                                   "dice_coef" : dice_coef,
                                                   "precision" : precision,
                                                   "sensitivity" :sensitivity,
                                                   "specificity" :specificity,
                                                   "dice_coef_necrotic" : dice_coef_necrotic,
                                                   "dice_coef_edema" : dice_coef_edema,
                                                   "dice_coef_enhancing" : dice_coef_enhancing
                                                  }, compile=False)

We specify the path to our saved model and provide a dictionary of custom_objects to ensure that our custom metrics and loss functions are correctly recognized by Keras. Setting compile=False allows us to load the model architecture and weights without compiling it immediately, giving us the flexibility to adjust compilation settings if needed.

11. Metrics Analysis

Now that the training is complete, we can examine the CSVLogger callback to gain insights into the training process and our model's performance. The CSVLogger records metrics such as accuracy, loss, Dice coefficient, and Mean IoU for each epoch, allowing us to track the model’s progress over time. By analyzing this log, we can identify trends, assess the effectiveness of our training strategy, and make informed decisions for future improvements. This thorough review ensures our model is performing optimally and ready for deployment.

In [114]:
import matplotlib.pyplot as plt
import pandas as pd

# Load the history
history = pd.read_csv('/kaggle/working/training.log', sep=',', engine='python')

# 🔍 THE FIX: Print the exact column names so we know how it's spelled
print("🚨 Exact columns in your CSV:", history.columns.tolist())
print("-" * 50)

# Temporarily plot just the 3 working metrics so it doesn't crash
f, ax = plt.subplots(1, 3, figsize=(16, 5)) 

epoch = range(len(history['accuracy']))

# Plot 1: Accuracy
ax[0].plot(epoch, history['accuracy'], 'b', label='Training Accuracy')
ax[0].plot(epoch, history['val_accuracy'], 'r', label='Validation Accuracy')
ax[0].legend()
ax[0].set_title('Accuracy')

# Plot 2: Loss
ax[1].plot(epoch, history['loss'], 'b', label='Training Loss')
ax[1].plot(epoch, history['val_loss'], 'r', label='Validation Loss')
ax[1].legend()
ax[1].set_title('Loss')

# Plot 3: Dice Coefficient
ax[2].plot(epoch, history['dice_coef'], 'b', label='Training Dice')
ax[2].plot(epoch, history['val_dice_coef'], 'r', label='Validation Dice')
ax[2].legend()
ax[2].set_title('Dice Coefficient')

plt.tight_layout()
plt.show()
🚨 Exact columns in your CSV: ['epoch', 'accuracy', 'dice_coef', 'dice_coef_edema', 'dice_coef_enhancing', 'dice_coef_necrotic', 'learning_rate', 'loss', 'mean_io_u_5', 'precision', 'sensitivity', 'specificity', 'val_accuracy', 'val_dice_coef', 'val_dice_coef_edema', 'val_dice_coef_enhancing', 'val_dice_coef_necrotic', 'val_loss', 'val_mean_io_u_5', 'val_precision', 'val_sensitivity', 'val_specificity']
--------------------------------------------------
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The accuracy graph shows that both training and validation accuracy increase over the epochs and reach a plateau, indicating that the model is learning from the data and generalizing well without overfitting.

The loss graph demonstrates that both training and validation losses decrease over time, further confirming that the model is effectively learning from the data. Notably, the best model performance is achieved around epoch 19, as indicated in the training logs.

Finally, the Dice coefficient graph shows a steady increase in both training and validation Dice coefficients, reinforcing that the model's segmentation capabilities are improving consistently.

12. Predict Tumor Segmentations

Now that our model is trained, we can use it to predict segmentations on our test dataset. There are two main options:

  1. Best Model's Weights (from epoch 19): Using the weights from the epoch where the model performed best.
  2. Final Model's Weights: Using the weights from the final epoch of training.

Using the final model's weights may not always yield the best performance on new, unseen data. In our case, there is no significant difference between the two options, so either can be used. However, for other cases, you might prefer a specific version of your model. You can load it with the following code:

In [118]:
import tensorflow as tf
from keras.layers import Input 

IMG_SIZE = 128
input_layer = Input((IMG_SIZE, IMG_SIZE, 2))

best_saved_model = build_unet(input_layer, 'he_normal', 0.2)

# FIXED: Changed 'tensorflow.keras...' to 'tf.keras...'
best_saved_model.compile(
    loss="categorical_crossentropy", 
    optimizer=tf.keras.optimizers.Adam(learning_rate=0.001), 
    metrics=['accuracy', tf.keras.metrics.MeanIoU(num_classes=4), dice_coef, precision, sensitivity, specificity, dice_coef_necrotic, dice_coef_edema, dice_coef_enhancing]
)

# Load the best weights
best_saved_model.load_weights('/kaggle/working/model_.21-0.026537.weights.h5')
print("✅ Best model weights loaded successfully!")
✅ Best model weights loaded successfully!
/opt/conda/lib/python3.10/site-packages/keras/src/saving/saving_lib.py:576: UserWarning: Skipping variable loading for optimizer 'adam', because it has 2 variables whereas the saved optimizer has 94 variables. 
  saveable.load_own_variables(weights_store.get(inner_path))

This allows you to select and use the optimal model version for your specific needs.


Now, let's construct a function to predict the segmentation of a patient in the test dataset. We will display the results in the axial plane, though any other plane can be chosen.

In [119]:
def imageLoader(path):
    image = nib.load(path).get_fdata()
    X = np.zeros((self.batch_size*VOLUME_SLICES, *self.dim, self.n_channels))
    for j in range(VOLUME_SLICES):
        X[j +VOLUME_SLICES*c,:,:,0] = cv2.resize(image[:,:,j+VOLUME_START_AT], (IMG_SIZE, IMG_SIZE));
        X[j +VOLUME_SLICES*c,:,:,1] = cv2.resize(ce[:,:,j+VOLUME_START_AT], (IMG_SIZE, IMG_SIZE));

        y[j +VOLUME_SLICES*c] = seg[:,:,j+VOLUME_START_AT];
    return np.array(image)
In [120]:
def loadDataFromDir(path, list_of_files, mriType, n_images):
    scans = []
    masks = []
    for i in list_of_files[:n_images]:
        fullPath = glob.glob( i + '/*'+ mriType +'*')[0]
        currentScanVolume = imageLoader(fullPath)
        currentMaskVolume = imageLoader( glob.glob( i + '/*seg*')[0] )
        # for each slice in 3D volume, find also it's mask
        for j in range(0, currentScanVolume.shape[2]):
            scan_img = cv2.resize(currentScanVolume[:,:,j], dsize=(IMG_SIZE,IMG_SIZE), interpolation=cv2.INTER_AREA).astype('uint8')
            mask_img = cv2.resize(currentMaskVolume[:,:,j], dsize=(IMG_SIZE,IMG_SIZE), interpolation=cv2.INTER_AREA).astype('uint8')
            scans.append(scan_img[..., np.newaxis])
            masks.append(mask_img[..., np.newaxis])
    return np.array(scans, dtype='float32'), np.array(masks, dtype='float32')
In [121]:
def predictByPath(case_path,case):
    files = next(os.walk(case_path))[2]
    X = np.empty((VOLUME_SLICES, IMG_SIZE, IMG_SIZE, 2))

    vol_path = os.path.join(case_path, f'BraTS20_Training_{case}_flair.nii');
    flair=nib.load(vol_path).get_fdata()

    vol_path = os.path.join(case_path, f'BraTS20_Training_{case}_t1ce.nii');
    ce=nib.load(vol_path).get_fdata()


    for j in range(VOLUME_SLICES):
        X[j,:,:,0] = cv2.resize(flair[:,:,j+VOLUME_START_AT], (IMG_SIZE,IMG_SIZE))
        X[j,:,:,1] = cv2.resize(ce[:,:,j+VOLUME_START_AT], (IMG_SIZE,IMG_SIZE))

    return model.predict(X/np.max(X), verbose=1)
In [125]:
def showPredictsById(case, start_slice = 60):
    path = f"/kaggle/input/brats20-dataset-training-validation/BraTS2020_TrainingData/MICCAI_BraTS2020_TrainingData/BraTS20_Training_{case}"
    gt = nib.load(os.path.join(path, f'BraTS20_Training_{case}_seg.nii')).get_fdata()
    origImage = nib.load(os.path.join(path, f'BraTS20_Training_{case}_flair.nii')).get_fdata()
    p = predictByPath(path,case)

    core = p[:,:,:,1]
    edema= p[:,:,:,2]
    enhancing = p[:,:,:,3]

    plt.figure(figsize=(18, 50))
    f, axarr = plt.subplots(1,6, figsize = (18, 50))

    for i in range(6): # for each image, add brain background
        axarr[i].imshow(cv2.resize(origImage[:,:,start_slice+VOLUME_START_AT], (IMG_SIZE, IMG_SIZE)), cmap="gray", interpolation='none')

    axarr[0].imshow(cv2.resize(origImage[:,:,start_slice+VOLUME_START_AT], (IMG_SIZE, IMG_SIZE)), cmap="gray")
    axarr[0].title.set_text('Original image flair')
    curr_gt=cv2.resize(gt[:,:,start_slice+VOLUME_START_AT], (IMG_SIZE, IMG_SIZE), interpolation = cv2.INTER_NEAREST)
    axarr[1].imshow(curr_gt, cmap="Reds", interpolation='none', alpha=0.3) # ,alpha=0.3,cmap='Reds'
    axarr[1].title.set_text('Ground truth')
    axarr[2].imshow(p[start_slice,:,:,1:4], cmap="Reds", interpolation='none', alpha=0.3)
    axarr[2].title.set_text('all classes predicted')
    axarr[3].imshow(edema[start_slice,:,:], cmap="OrRd", interpolation='none', alpha=0.3)
    axarr[3].title.set_text(f'{SEGMENT_CLASSES[1]} predicted')
    axarr[4].imshow(core[start_slice,:,], cmap="OrRd", interpolation='none', alpha=0.3)
    axarr[4].title.set_text(f'{SEGMENT_CLASSES[2]} predicted')
    axarr[5].imshow(enhancing[start_slice,:,], cmap="OrRd", interpolation='none', alpha=0.3)
    axarr[5].title.set_text(f'{SEGMENT_CLASSES[3]} predicted')
    plt.show()
In [126]:
showPredictsById(case=test_ids[0][-3:])
4/4 ━━━━━━━━━━━━━━━━━━━━ 21s 2s/step
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In [127]:
showPredictsById(case=test_ids[1][-3:])
4/4 ━━━━━━━━━━━━━━━━━━━━ 0s 57ms/step
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In [128]:
showPredictsById(case=test_ids[2][-3:])
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In [129]:
showPredictsById(case=test_ids[3][-3:])
4/4 ━━━━━━━━━━━━━━━━━━━━ 0s 54ms/step
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In [130]:
showPredictsById(case=test_ids[4][-3:])
4/4 ━━━━━━━━━━━━━━━━━━━━ 0s 58ms/step
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In [131]:
showPredictsById(case=test_ids[5][-3:])
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In [132]:
showPredictsById(case=test_ids[6][-3:])
4/4 ━━━━━━━━━━━━━━━━━━━━ 0s 59ms/step
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In [135]:
def predict_segmentation(sample_path):
    # Load NIfTI (.nii) files of the sample (patient)
    t1ce_path = sample_path + '_t1ce.nii'
    flair_path = sample_path + '_flair.nii'

    # Extract the data from these paths
    t1ce = nib.load(t1ce_path).get_fdata()
    flair = nib.load(flair_path).get_fdata()

    # Create an empty array
    X = np.empty((VOLUME_SLICES, IMG_SIZE, IMG_SIZE, 2))

    # Perform the same operations as our DataGenerator, to keep the same input shape
    for j in range(VOLUME_SLICES):
        X[j,:,:,0] = cv2.resize(flair[:,:,j+VOLUME_START_AT], (IMG_SIZE,IMG_SIZE))
        X[j,:,:,1] = cv2.resize(t1ce[:,:,j+VOLUME_START_AT], (IMG_SIZE,IMG_SIZE))

    # Send our images to the CNN model and return predicted segmentation
    return model.predict(X/np.max(X), verbose=1)
In [138]:
def show_predicted_segmentations(samples_list, slice_to_plot, cmap, norm):
    # Choose a random patient
    random_sample = random.choice(samples_list)

    # Get path of this patient
    random_sample_path = os.path.join(TRAIN_DATASET_PATH, random_sample, random_sample)

    # Predict patient's segmentation
    predicted_seg = predict_segmentation(random_sample_path)

    # Load patient's original segmentation (Ground truth)
    seg_path = random_sample_path + '_seg.nii'
    seg = nib.load(seg_path).get_fdata()

    # Resize original segmentation to the same dimensions of the predictions. (Add VOLUME_START_AT because original segmentation contains 155 slices vs only 75 for our prediction)
    seg=cv2.resize(seg[:,:,slice_to_plot+VOLUME_START_AT], (IMG_SIZE, IMG_SIZE), interpolation = cv2.INTER_NEAREST)

    # Differentiate segmentations by their labels
    all = predicted_seg[slice_to_plot,:,:,1:4] # Deletion of class 0 (Keep only Core + Edema + Enhancing classes)
    zero = predicted_seg[slice_to_plot,:,:,0] # Isolation of class 0, Background (kind of useless, it is the opposite of the "all")
    first = predicted_seg[slice_to_plot,:,:,1] # Isolation of class 1, Core
    second = predicted_seg[slice_to_plot,:,:,2] # Isolation of class 2, Edema
    third = predicted_seg[slice_to_plot,:,:,3] # Isolation of class 3, Enhancing

    # Plot Original segmentation & predicted segmentation
    print("Patient number: ", random_sample)
    fig, axstest = plt.subplots(1, 6, figsize=(25, 20))

    # Original segmentation
    axstest[0].imshow(seg, cmap, norm)
    axstest[0].set_title('Original Segmentation')

    # Layers 1, 2, 3
    axstest[1].imshow(all, cmap, norm)
    axstest[1].set_title('Predicted Segmentation - all classes')

    # Layer 0
    axstest[2].imshow(zero)
    axstest[2].set_title('Predicted Segmentation - Not Tumor')

    # Layer 1
    axstest[3].imshow(first)
    axstest[3].set_title('Predicted Segmentation - Necrotic/Core')

    # Layer 2
    axstest[4].imshow(second)
    axstest[4].set_title('Predicted Segmentation - Edema')

    # Layer 3
    axstest[5].imshow(third)
    axstest[5].set_title('Predicted Segmentation - Enhancing')

    # Add space between subplots
    plt.subplots_adjust(wspace=0.8)

    plt.show()
In [148]:
import matplotlib.colors as mcolors
# 0 = Background (Black)
# 1 = Necrotic / Non-enhancing tumor core (Red)
# 2 = Peritumoral Edema (Green)
# 3 = GD-Enhancing Tumor (Yellow)
cmap_colors = ['black', 'red', 'green', 'yellow']
cmap = mcolors.ListedColormap(cmap_colors)
bounds = [0, 1, 2, 3, 4]
norm = mcolors.BoundaryNorm(bounds, cmap.N)
show_predicted_segmentations(test_ids, 60, cmap, norm)
show_predicted_segmentations(test_ids, 65, cmap, norm)
4/4 ━━━━━━━━━━━━━━━━━━━━ 0s 59ms/step
Patient number:  BraTS20_Training_311
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4/4 ━━━━━━━━━━━━━━━━━━━━ 0s 39ms/step
Patient number:  BraTS20_Training_311
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In [149]:
case = test_ids[3][-3:]
path = f"/kaggle/input/brats20-dataset-training-validation/BraTS2020_TrainingData/MICCAI_BraTS2020_TrainingData/BraTS20_Training_{case}"
gt = nib.load(os.path.join(path, f'BraTS20_Training_{case}_seg.nii')).get_fdata()
p = predictByPath(path,case)

core = p[:,:,:,1]
edema= p[:,:,:,2]
enhancing = p[:,:,:,3]

i=40 # slice at
eval_class = 2 #     0 : 'NOT tumor',  1 : 'ENHANCING',    2 : 'CORE',    3 : 'WHOLE'

gt[gt != eval_class] = 1 # use only one class for per class evaluation

resized_gt = cv2.resize(gt[:,:,i+VOLUME_START_AT], (IMG_SIZE, IMG_SIZE))

plt.figure()
f, axarr = plt.subplots(1,2)
axarr[0].imshow(resized_gt, cmap="gray")
axarr[0].title.set_text('ground truth')
axarr[1].imshow(p[i,:,:,eval_class], cmap="gray")
axarr[1].title.set_text(f'predicted class: {SEGMENT_CLASSES[eval_class]}')
plt.show()
4/4 ━━━━━━━━━━━━━━━━━━━━ 0s 54ms/step
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13. Evaluation

Let's call the evaluate() function to evaluate the performance of our model on our test dataset:

In [150]:
# Evaluate the model on the test data
model.compile(loss="categorical_crossentropy",
              optimizer=keras.optimizers.Adam(learning_rate=0.001),
              metrics = ['accuracy',tf.keras.metrics.MeanIoU(num_classes=4), dice_coef, precision, sensitivity, specificity, dice_coef_necrotic, dice_coef_edema, dice_coef_enhancing])

results = model.evaluate(test_generator, batch_size=100, callbacks= callbacks)

descriptions = ["Loss", "Accuracy", "MeanIOU", "Dice coefficient", "Precision", "Sensitivity", "Specificity", "Dice coef Necrotic", "Dice coef Edema", "Dice coef Enhancing"]

# Combine results list and descriptions list
results_list = zip(results, descriptions)

# Display each metric with its description
print("\nModel evaluation on the test set:")
print("==================================")
for i, (metric, description) in enumerate(results_list):
    print(f"{description} : {round(metric, 4)}")
/opt/conda/lib/python3.10/site-packages/keras/src/trainers/data_adapters/py_dataset_adapter.py:121: UserWarning: Your `PyDataset` class should call `super().__init__(**kwargs)` in its constructor. `**kwargs` can include `workers`, `use_multiprocessing`, `max_queue_size`. Do not pass these arguments to `fit()`, as they will be ignored.
  self._warn_if_super_not_called()
45/45 ━━━━━━━━━━━━━━━━━━━━ 46s 952ms/step - accuracy: 0.9925 - dice_coef: 0.6241 - dice_coef_edema: 0.6891 - dice_coef_enhancing: 0.7391 - dice_coef_necrotic: 0.6014 - loss: 0.0222 - mean_io_u_11: 0.6132 - precision: 0.9933 - sensitivity: 0.9909 - specificity: 0.9977

Model evaluation on the test set:
==================================
Loss : 0.022
Accuracy : 0.9927
MeanIOU : 0.5
Dice coefficient : 0.6124
Precision : 0.9934
Sensitivity : 0.9911
Specificity : 0.9978
Dice coef Necrotic : 0.5687
Dice coef Edema : 0.6995
Dice coef Enhancing : 0.7084

The final evaluation of our model on the test set yields impressive results, demonstrating its effectiveness in segmenting brain tumors.

These metrics indicate that our model performs exceptionally well across various evaluation criteria:

  • Accuracy and Precision are both above 99%, showcasing the model’s reliability in correctly identifying tumor and non-tumor regions.
  • Mean IoU of 0.8426 and Dice Coefficient of 0.6480 highlight strong overlap between predicted and actual segmentations.
  • Sensitivity of 0.9916 and Specificity of 0.9978 emphasize the model’s capability to correctly identify true positives and true negatives.
  • Specific Dice Coefficients for necrotic (0.5916), edema (0.7667), and enhancing (0.7395) regions reflect good performance in segmenting different tumor components.

Overall, these results demonstrate that our model has robust generalization capabilities and can effectively segment brain tumors in unseen data.